منابع مشابه
Cancer chemoresistance and BAK
Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upon cell survival. Interestingly though, many cancers have intact apoptotic machinery where mutation rates of key regulators is very low the BCL-2 fa...
متن کاملBak - Sneppen Model
R. Cafiero, P. De Los Rios, A. Valleriani, and J. L. Vega 1 P.M.M.H., Ecole Supérieure de Physique et de chimie Industrielles, 10, rue Vaquelin, 75231 Paris, France. 2 Institut de Physique Theorique, Université de Fribourg, CH-1700 Fribourg, Switzerland. 3 Max-Planck-Institute of Colloids and Interfaces Theory Division Kantstrasse 55, D-14513 Teltow-Seehof, Germany 4 BANCOTEC GmbH, Calwerstraße...
متن کاملColloquium Paper : Bak and Paczuski
Complexity originates from the tendency of large dynamical systems to organize themselves into a critical state, with avalanches or "punctuations" of all sizes. In the critical state, events which would otherwise be uncoupled become correlated. The apparent, historical corntingency in many sciences, including geology, biology, and economics, finds a natural interpretation as a self-organized cr...
متن کاملBak to death with chemotherapy.
BH3 mimetics, such as AT-101, are designed to interfere with various antiapoptotic proteins such as bcl-2, bcl-XL, and mcl-1, thus activating Bax and Bak; these mimetics ultimately promote apoptosis through a complicated pathway (see figure). When a malignant lymphocyte is exposed to chemotherapy, modulation of the cellular apoptotic threshold through this pathway could significantly enhance cy...
متن کاملBAK additive influence on results
Submit your manuscript here: http://www.dovepress.com/clinical-ophthalmology-journal Clinical Ophthalmology is an international, peer-reviewed journal covering all subspecialties within ophthalmology. Key topics include: Optometry; Visual science; Pharmacology and drug therapy in eye diseases; Basic Sciences; Primary and Secondary eye care; Patient Safety and Quality of Care Improvements. This ...
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ژورنال
عنوان ژورنال: Nature
سال: 2002
ISSN: 0028-0836,1476-4687
DOI: 10.1038/420284a